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Ocular Manifestations of Diabetes Beyond Retinopathy

Posted by Talin Amadian on Dec 10, 2021 12:00:00 AM

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Artboard 1-4Diabetes is a systemic condition that can affect the entire body, including the eyes. Most clinicians focus on diabetic retinopathy as the primary ocular manifestation of diabetes.

However, diabetes can increase the likelihood of so many other ocular conditions. Here’s a shortlist of other conditions to watch out for when examining a patient with diabetes who may or may not present with retinopathy. 

Glaucoma: Patients with diabetes are at risk for developing primary open-angle glaucoma as well as neovascular glaucoma. Five percent of patients with diabetes present with primary open-angle glaucoma compared to only two percent of the general population. Some studies also show that patients with diabetes are twice as likely to have glaucoma compared to those without. Studies have also shown an association between neovascular glaucoma and diabetes. However, neovascular glaucoma is more likely to present after the development of proliferative diabetic retinopathy. 

Cataracts: Cataracts are a major cause of vision impairment in patients with diabetes according to many studies. Not only does diabetes contribute to cataracts, but it can also affect outcomes of cataract surgery should the patient have active proliferative retinopathy and/or persistent macular edema. 

Hypertensive Retinopathy: Most patients with diabetes have hypertension. Hypertensive retinopathy can present similarly to diabetic retinopathy with hemorrhaging and cotton wool spots.

Anterior ischemic optic neuropathy: 25% of patients with AION have a history of diabetes, leading to ischemia to the anterior aspect of the optic nerve. 

Ocular movement disorders: Ocular movement disorders can be caused by diabetes affecting the third, fourth, or sixth cranial nerves. Diabetes is the biggest underlying cause of cranial nerve palsies. 

Retinal vein occlusion (RVO): Diabetes is a major risk factor for retinal vein occlusions, which similarly to diabetes can present as dilated veins, hemorrhages, cotton wool spots, and macular edema. 

Ocular Ischemic Syndrome (OIS): Though ocular ischemic syndrome is an uncommon problem, most patients with OIS have diabetes since diabetes can result in carotid artery stenosis and plaque formation which can lead to OIS.

~ Dr. Amadian

Topics: Diabetes



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